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Using a Pamas particle counter for parts cleanliness

courtesy of Pamas

partsYou can measure the cleanliness of components and packing materials with an automatic particle counter. The surface cleanliness is analysed indirectly by
removing any particles from the surface through flushing, hosing, flooding or placing the item in an ultrasonic bath. The rinsing fluid is analysed with the liquid
particle counter. The surface contamination is calculated by comparing the results with a blank measurement of the clean rinsing fluid.

 

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Dynamic Vapor Sorption Strengthens Tablet Coating Evaluation

Surface Measurement Systems has demonstrated how Dynamic Vapor Sorption (DVS) can serve as a powerful Process Analytical Technology (PAT) tool for pharmaceutical manufacturers seeking to optimize tablet film coatings.

Film coatings are critical for moisture‑sensitive products, directly influencing drug stability, safety, and efficacy. Traditional methods such as Karl Fischer titration or long‑term storage studies often lack the sensitivity to detect subtle differences in coating quality. DVS, by contrast, provides real‑time, quantitative insight into moisture uptake, sorption kinetics, and diffusion behavior under controlled humidity and temperature conditions.

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Breweries have special requirements


Onlinepamascourtesy of Pamas

People say, and genuinely believe, that beer is the favourite drink in Germany. Also, beer is the global market leader of alcoholic beverages. For centuries, breweries have had to fulfil the highest of quality standards. In addition to the brewing ingredients, the manufacturing process is strictly monitored too. An important step in beer production is filtration. Using laser particle counters, beer filtration can be accurately monitored and continuously optimized.

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Dataphysics Introduces One‑Click Stability Evaluation with MSI

Filderstadt, GermanyDataphysics Instruments has unveiled a powerful new tool for dispersion analysis: the Multiscan Stability Index (MSI), available on the MultiScan MS 20 system. Designed to simplify the evaluation of complex destabilisation phenomena such as sedimentation, aggregation, and creaming, MSI delivers a single, quantitative value that reflects the overall stability of a formulation.

The MultiScan MS 20 employs static multiple light scattering (SMLS) to monitor transmitted and backscattered light across the full sample height over time. Traditionally, interpreting these signals required expert analysis, especially when multiple destabilisation processes occurred simultaneously. MSI eliminates this barrier by condensing spatial and temporal variations into one stability number – the closer to zero, the more stable the sample.

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10 Practical Tips for GMP Cleanroom Contamination Monitoring

courtesy of Particle Measuring Systems

GMP cleanroom contamination monitoring is a critical safeguard, forming the frontline defense against risks that can compromise product quality. When executed with intention and rigor, it becomes one of your most powerful tools for detecting contamination risks early and stopping issues before they escalate.

Aligned with EU GMP Annex 1, these ten practical tips are designed to help you build a monitoring program that is not only robust and defensible, but actively protects your product, the patients, and the integrity of your facility. 

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Recommended test liquids selection for surface energy determination

courtesy of DataPhysics Instruments

dropSurface free energy (SFE) is one of the most critical surface parameters in industrial manufacturing processes such as painting,
coating, printing, and adhesive bonding. The success of these processes strongly depends on proper wetting of the
substrate surface — and wetting behavior is directly governed by the surface free energy of the solid. A widely used method
for determining solid SFE is the Owens–Wendt–Rabel–Kaelble (OWRK) method, which divides the total surface energy into
two components: Dispersive (non-polar) and Polar.

 

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PAMAS AS3 - automated particle counter for liquids

written by Albrecht Truter

The Pamas AS3 is a rather unique system as it is a fully automated particle counting instrument that can measure up to 600
samples per day unattended.It takes automation of particle counting to the next level. The idea of an particle counter connected
to a XY liquid sampler seems routine, but Pamas takes the idea to a whole new level with their many years of experience 
manufacturing  particle counters.

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Normalized Data in Microbial Continuous Monitoring

courtesy of  Particle Measuring Systems

 Get a clear, practical breakdown of viable active air sampling for Grade A and B cleanrooms. This paper covers the key factors for effective sampling,
a recommended approach for microbial monitoring, real‑world calculation examples for routine continuous sampling, insights on alternatives to
CFU/m³ in Grade B areas, and conclusions from a PMS perspective. Download now to sharpen your environmental monitoring strategy.

 

 

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Evaluating the interfacial tension between ink and different dampening solutions used in offset printing

courtesy of DataPhysics Instruments

print Offset printing is a widely used technique in the production of printed products such as books, newspapers, and packaging. The process relies on the transfer of an image from an inked surface to the substrate. When used in combination with a lith­ographic process, it comprises the use of a dampening solution and an oil-based printing ink. The inked surface (plate) is di­vided into hydrophilic regions, which accept the dampening solution and repel the ink, and hydrophobic regions which repel the dampening solution and accept the ink.

 If the process is functioning optimally, it can be confirmed that the non-printing regions of the plate are devoid of ink. It is essential to ascertain the precise interfacial tension between the dampening solu­tion and the printing ink at the interface to avert the possibility of their mixing. The OCA system, developed by DataPhysics Instruments, is a highly robust and reliable apparatus for measuring the optical contact angle and performing contour analysis. The system employs the pendant drop method to accurately determine interfacial tension between liquid/liquid interfaces. The following note will illustrate the pendent drop technique with ink and three different dampening solutions commonly utilised in offset printing.

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Cleanroom Classification

Written by Maurizio Della Pietra
Part 1 of 5 part blog on : Cleanroom Classification – Qualification – Monitoring Per EU GMP Annex 1, rev 12 draft

Cleanroom Classification
Annex 1 provides essentially the same cleanroom classification definition as ISO 14644-1: 2015 which

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Formulation Performance

courtesy of Surface Measurement Systems

powderThe formulation performance of a product can be affected in a variety of ways by moisture present in the air.
The stability of these formulations is paramount to their efficacy. Both DVS and iGC-SEA can be used to
examine how a product dries, the deposition of product, the adhesive properties of a powder blend,
and the stabilization effects of protein stabilizers. 

 

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Particle Loss Studies

courtesy of Particle Measuring Systems

gownIn aseptic pharmaceutical production, undetected airborne particle contamination from tubing systems can jeopardize
sterility assurance and lead to audit failures.EU GMP Annex 1 and ISO 14644-TR21 now require a deeper understanding
and control of particle transport risks in all types of installations, including traditional legacy systems, isolators,
and RABS-based filling machines.

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Safety in oil transformers due to PAMAS particle counters

Applications from Surface Measurment Systems

courtesy of Surface Measurement Systems 

Sorption Science is employed for a variety of applications across a range of industries, and our instruments are designed to reflect that.

As top-of-the-line sorption analyzers, our products can be employed across a huge range of applications, provide detailed and accurate data whatever your research purpose.

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Environmental Monitoring Best Practices Handbook *New Volume 2026*

courtesy of Particle Measuring Systems

Environmental monitoring in pharmaceutical manufacturing is more than compliance; it demands practical, reliable strategies for complex controlled environments. This second volume of the Environmental Handbook offers practical guidance for environmental monitoring in glove boxes and isolators, defining microbial sampling criteria, addressing Annex 1 (2022) changes, and examining particle loss in transport tubing. It also covers risk assessment for isolator filling, microbiological sampling techniques, sample‑collection strategies, and data interpretation, supporting effective contamination control and confident decision‑making.

Volume 2 of the Environmental Monitoring Handbook for Pharmaceutical Manufacturers is your updated, essential guide to a deeper understanding of environmental monitoring. The second volume offers a completely new set of materials, including two updated application notes and six chapters written specifically to support this expanded handbook. Chapters cover isolator and glove‑box monitoring, updated microbial and particle sampling criteriaparticle‑loss challenges, a risk assessment framework for isolator filling processes, and expert insight on sample collection and Annex 1 changes.

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Rapid assessment of cleaning agent performance after cooling lubricant application using the PCA 200

courtesy of DataPhysics

The effective removal of cooling lubricants is essential for ensuring high surface quality and reliable downstream processing.
Contact angle measurements and free surface energy (SFE) analysis offer a fast, efficient, and non-destructive method for
evaluating the performance of cleaning agents after cooling lubricant application. By characterising surface wettability,
residual contamination and cleaning effectiveness can be quantitatively assessed, enabling informed decisions to optimize
processes and conserve resources.

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The New ISO 4407 – A Milestone for Microscopic Particle Analysis

courtesy of Pamas

After several years of intensive revision, the updated version of ISO 4407 has finally been released. This marks a real milestone for professionals working in microscopic particle analysis. The new edition of ISO 4407 is ready for the future – practical, open to new technologies, and fully aligned with modern quality processes.

Anyone working with microscopes knows it: ISO 4407 – the standard for manual particle counting on filter membranes. It serves as the counterpart to ISO 11171, which governs the calibration of automatic particle counters for liquids. But while ISO 11171 has undergone continuous updates and adjustments over the years, ISO 4407 remained largely unchanged since the 1980s – until now.

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Pamas S50P Fuel

courtesy of Pamas 

PAMAS S50P FuelThe online particle counter PAMAS S50P Fuel is used asa online measuring instrument for condition monitoring and contamination analysis of liquid fuel(e.g. diesel). The instrument measures the number of particles in eight different size channels and can function as early alerts in case of failures caused by bigger particle sizes (e.g. corrosion). This makes PAMAS S50P Fuel indispensable for preventive condition monitoring of liquid fuel, as it prevents the filling of contaminated fuel into storage tanks. On its 6-digit LED display, the instrument reports the triple code according to ISO 4406. The PAMAS S50P Fuel is equipped with a pump to control the flow rate to 25 ml/min at a pressure range from 0 to 6 bar.

 

 

 

 

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Environmental Monitoring Best Practices Handbook

courtesy of Particle Measuring Systems

Environmental Monitoring HandbookEnvironmental monitoring in pharmaceutical manufacturing isn’t just about meeting requirements—
it’s about applying them effectively to protect product integrity and patient safety. Grounded in real-world
experience, this handbook translates EU GMP Annex 1 (2022) expectations and Contamination Control Strategy
(CCS) principles into clear, practical guidance. It helps teams strengthen cleanroom control, support compliance,
and maintain confidence in product quality across daily operations.

The Environmental Monitoring Handbook for Pharmaceutical Manufacturers is your essential guide to mastering
cleanroom operations. Whether you’re navigating the latest EU GMP Annex 1 (2022) updates or implementing a robust
 Contamination Control Strategy (CCS), this handbook delivers:

  • Actionable insights into monitoring systems, tools, and best practices
  • Clear guidance on particle counting technologies and regulatory compliance
  • Real-world strategies to bridge the gap between theory and practice

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PAMAS FastPatch 2 GO

courtesy of Pamas

FastPatch 2The microscope system PAMAS FastPatch 2 GO has been developed to comply with
the standard ISO 4407 as an automated filter membrane particle counting and sizing
system.

The system is designed to measure the particles trapped on the surface of the filter.
The analysis uses advanced image analysis and microscope automation techniques
to provide rapid and accurate contamination results of whole or user specified areas of filters.

The FastPatch 2 GO is especially suitable for:

Dark oils, 2 -phase emulsion or high levels of contamination

  

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Featured webinars from Surface Measurment Systems

courtesy of Albrecht Truter

sms2026Surface Measurement  Systems series of online educational events provide an in-depth look at the diverse ways of their
techniques and instruments. Covering an array of industrial applications, their own scientists have worked closely
with clients and partners around the world to curate an expansive library of sorption-focused educational content
from practitioners all over the world.

 

 

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Contamination Control in Battery Manufacturing: Enhancing Safety and Yield

courtesy of Particle Measuring Systems

Battery manufacturing demands precise control of particulate and molecular contamination to safeguard safety, performance,
and yield. As production scales and processes remain tightly interconnected, robust contamination monitoring brings stability to
operations, minimizes defects, and reduces the risk of costly interruptions. Grounded in real-world manufacturing experience,
this technical paper presents data-driven monitoring approaches that help battery manufacturers maintain control, ensure
consistent quality, and protect yield across the production lifecycle. 

 

 

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Why measure particles in fuel and hydraulic fluids?

by Albrecht Truter

S40 and SBSSAn liquid particle counter measures the number and size of the particles in a liquid, but why bother to do that ?
This short article will answer that question.

In the case of hydraulic fluids the hydraulic compents has fine tollerances which can be damaged by to
many particles in the fluid.When maintenance are completed it also best practise to flush the system with clean hyraulic fluid and check the fluid is clean
after the flush before placing the system back into service. Trend monitoring of hydraulic fluids also serve as an early warning of abnormal wear and
possible impending failure in a system.

 

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Selecting the Best Particle Counter for Your Needs (Series Part 1 of 4)

Written by 

Particle Counter Terminology and Standards

Your need to find the best particle counter for your application depends on monitoring environment, communications, desired flow rate, and the particle sizes of interest. Don’t know where to start? Read on for an overview of the basics for choosing the method to monitor your process air.

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